AI-powered research
for the hardest problems.

Like One Foundation conducts and funds research at the intersection of artificial intelligence, disability accessibility, and HIV cure science. All tools are open-source. All findings are open-access.

Where we work.

🧬

HIV Cure Science

Active

Automated literature review and synthesis across 35,000+ HIV cure papers. Tracking latent reservoir elimination, broadly neutralizing antibodies, gene therapy, and therapeutic vaccines.

UCSF · amfAR · Wistar Institute
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Human-AI Convergence

Active

Investigating persistent AI memory, autonomous agent architectures, and cyborg accessibility. How disabled people use AI as cognitive prosthetics — not tools, but extensions of self.

Like One Foundation
🏛️

AI-Powered Archaeology

New

LiDAR + satellite + deep learning for autonomous archaeological feature detection. Multi-modal fusion of 3DEP elevation data and Sentinel-2 imagery for cultural resource management.

Like One Foundation

Disability & Assistive AI

Active

Building AI systems that carry cognitive load for disabled users. Autonomous email, document signing, grant writing, and life management — technology as civil right, not luxury.

Like One Foundation

Research infrastructure we build and share.

Every research tool we build is designed to run locally, respect privacy, and work autonomously. No API keys required for core functionality. Built on Ollama, Playwright, and SQLite.

lo-research

Multi-source academic search engine. Semantic Scholar, PubMed, arXiv. 6-agent pipeline with Ollama summarization.

59 papers indexed

lo-dig

Drone archaeology + AI. LiDAR processing, satellite analysis, HRNet anomaly detection. Georeferenced GeoTIFF output.

Prototype complete

lo-foundation

Autonomous 501(c)(3) grant discovery and application engine. Grants.gov API + Playwright + AI drafting.

56 grants tracked

Preprints & papers.

We publish our findings as open-access preprints. Academic profiles and formal publications are in progress.

Coming Soon

First preprints in preparation: Human-AI Convergence and HIV Cure Literature Review. Profiles on ORCID, Google Scholar, and arXiv forthcoming.

Sovereign research infrastructure.

1

Local-first

All models run on-device via Ollama. No data leaves your machine. No API costs for core research.

2

Multi-source

Semantic Scholar, PubMed, arXiv searched simultaneously. Deduplication and cross-referencing built in.

3

AI-synthesized

6-agent pipeline: search, filter, summarize, synthesize, cite, review. Literature reviews in minutes, not months.

4

Open-access

All preprints on arXiv/Zenodo. All tools on GitHub. Research should be free.

“The disabled queer trans woman the system tried to delete builds the machine that saves everyone. That’s not aspiration. That’s the architecture.”
— Sophia Cave, Founder
Like One Foundation • 501(c)(3)

Fund the research.

Every course sold funds HIV cure research. Every tool we build is open-source. Support the mission or use our tools — either way, you’re helping.